Optimization In Drug Discovery: In Vitro Methods (Methods In Pharmacology And Toxicology)

Thoroughly revised and updated, Optimization in Drug Discovery: In Vitro Methods, Second Edition presents a wide spectrum of in vitro assays including formulation, plasma binding, absorption and permeability, cytochrome P450 (CYP) and UDP-glucuronosyltransferases (UGT) metabolism, CYP inhibition and induction, drug transporters, drug-drug interactions via assessment of reactive metabolites, genotoxicity, and chemical and photo-mutagenicity assays. Written for the Methods in Pharmacology and Toxicology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible protocols, and tips on troubleshooting and avoiding known pitfalls. Expert authors have developed and utilized these in vitro assays to achieve “drug-like” characteristics in addition to efficacy properties and good safety profiles of drug candidates. Comprehensive and up-to-date, Optimization in Drug Discovery: In Vitro Methods, Second Edition aims to guide researchers down the difficult path to successful drug discovery and development.

• | Author: Gary W. Caldwell|Zhengyin Yan, Gary W. Caldwell
• | Publisher: Humana
• | Publication Date: Aug 23, 2016
• | Number of Pages: 614 pages
• | Language: English
• | Binding: Paperback/Medical
• | ISBN-10: 1493960709
• | ISBN-13: 9781493960705