Cover Page -- Title Page -- Copyright page -- Contents -- List of Contributors -- Introduction: Medical Proofs, Social Experiments: Clinical Trials in Shifting Contexts -- PART I THE PRACTICES OF RESEARCH -- 1 Reconciling Research with Medical Care in RCTs -- 2 Bridging the Ontological Divide: Different Social Worlds in the Conduct of a Pilot Study -- 3 From Dirty Data to Credible Scientific Evidence: Some Practices Used to Clean Data in Large Randomised Clinical Trials1 -- PART II FRAMING COLLECTIVE INTERPRETATION -- 4 Addressing the Commercial Context: The Collective Critique of Clinical Trials -- 5 When are Trials Not Enough? Clinical Versus Cost-effectiveness in the Controversy Over Access to Dementia Drugs in the NHS -- PART III TESTING THE LIMITS FOR POLICY -- 6 Comparing Artificial Groups: On the History and Assumptions of the Randomised Controlled Trial1 -- 7 Pragmatic Fact-making: Contracts and Contexts in the UK and the Gambia -- 8 Trial, Trial, Trial Again: Reconstructing the Gold Standard in the Science of Prostate Cancer Detection -- Conclusion: So What? -- Bibliography