Oral Bioavailability Assessment: Basics and Strategies for Drug Discovery and Development (Wiley Series on Pharmaceutical Science and Biotechnology: Practices, Applications and Methods)

Specifically geared to personnel in the pharmaceutical and biotechnology industries, this book describes the basics and challenges of oral bioavailability û one of the most significant hurdles in drug discovery and development. ò Describes approaches to assess pharmacokinetics and how drug efflux and uptake transporters impact oral bioavailability ò Helps readers reduce the failure rate of drug candidates when transitioning from the bench to the clinic during development ò Explains how preclinical animal models û used in preclinical testing û and in vitro tools translate to humans, which is an underappreciated and complicated area of drug development ò Includes chapters about pharmacokinetic modelling, the Biopharmaceutics Drug Disposition Classification System (BDDCS), and the Extended Clearance Classification System (ECCS) ò Has tutorials for applying strategies to medicinal chemistry practices of drug discovery/development

• | Author: Ayman F. El-Kattan
• | Publisher: Wiley
• | Publication Date: Jun 06, 2017
• | Number of Pages: 448 pages
• | Language: English
• | Binding: Hardcover/Medical
• | ISBN-10: 1118916697
• | ISBN-13: 9781118916698