Allostery: Methods and Protocols (Methods in Molecular Biology)

This volume explores the basic issues of ôallosteryö and ônetworkö that are fundamental to studying this field. Chapters in this book look at how the basic ômachine-likeö proteins, that are similar to ôhuman machines,ö need to be organized, architecturally, to relate to different organizational layers. Chapters cover topics such as methodological/computational factors focused on links between allostery and network formalism; the presence of oscillating modes transversing the structure and underlying network wiring of the allosteric process; the ôaction at distanceö by transduction of signals across an organized network structure; and the P53 protein located at the cross-road of cell cycle regulation, genome integrity, and cancer development. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Thorough and practical, Allostery: Methods and Protocols is a valuable resource for any scientists and researcher interested in learning more about this developing field.

• | Author: Luisa Di Paola, Alessandro Giuliani
• | Publisher: Humana
• | Publication Date: Dec 16, 2021
• | Number of Pages: 288 pages
• | Language: English
• | Binding: Paperback/Science
• | ISBN-10: 1071611569
• | ISBN-13: 9781071611562