Drug-Drug Interactions - 9780367452742

Authored by renowned leaders in the field, this comprehensive volume covers all aspects of drug-drug interactions, including preclinical, clinical, toxicological, and regulatory perspectives. Thoroughly updated, this second edition reflects the significant advances and includes extensive new material on: key interplay between transporters and enzymes in drug metabolism and drug interactions the integral role of pharmacogenetics in metabolism-based drug-drug interactions in vivo - in vitro correlations (reversible, mechanism-based inhibition, induction) in silico approaches enabling structure-activity and structure-function studies high-throughput screening and GLP methods for evaluating drug interactions in vitro the use of transgenic animal models to evaluate drug interactions Providing helpful case examples and computer-aided modeling, Drug-Drug Interactions is filled with over 200 invaluable tables, equations, and figures to clarify key concepts, and incorporates critical new updated information.

• | Author: A. David Rodrigues
• | Publisher: Crc Press
• | Publication Date: Dec 02, 2019
• | Number of Pages: 768 pages
• | Language: English
• | Binding: Paperback
• | ISBN-10: 036745274X
• | ISBN-13: 9780367452742