In Silico Drug Design: Repurposing Techniques and Methodologies

Over the years, biological and chemical information has been generated at an ever-increasing pace offering the scientific community new opportunities to link drugs to diseases. It is particularly beneficial in evaluating repositioning opportunities for older drugs based on the available data. The advantages of drug repurposing are reduced development cost, a better return on investment, and an accelerated development time. In Silico Drug Design: Repurposing Techniques and Methodologies explores these opportunities and how the application of computational tools can be utilized for this approach. The book covers theoretical background and methodologies of chem-bioinformatic techniques and network modeling and discusses the various applied strategies to systematically retrieve, integrate, and analyze datasets from diverse sources. Other topics include in silico drug design methods, computational workflows for drug repurposing, and network-based in silico screening for drug efficacy. With contributions from experts in the field and the inclusion of practical case studies, In Silico Drug Design benefits scientists, researchers, and R&D professionals in the pharmaceutical industry engaged in drug development and design. Discusses the theoretical background and methodologies of useful techniques of cheminformatics and bioinformatics that can be applied for drug repurposing Offers case studies in silico modeling of FDA-approved drugs for the discovery of antifungal, anticancer, antiplatelet agents and for drug therapies against diseases Covers tools and databases that can be utilized to facilitate in silico methods for drug repurposing

• | Author: Kunal Roy
• | Publisher: Academic Press
• | Publication Date: Feb 15, 2019
• | Number of Pages: 886 pages
• | Language: English
• | Binding: Paperback
• | ISBN-10: 0128161256
• | ISBN-13: 9780128161258